The effects of cigarette smoking on T cell subsets. A population-based survey of healthy caucasians.

摘要: To investigate the influence of cigarette smoking on mononuclear cell subsets, we determined T cell, B monocyte, and HLA-DR+ subsets in a population-based, stratified, random sample healthy Caucasians using monoclonal antibodies flow cytometry. The study population consisted 282 subjects 20 to 69 yr age, including 108 smokers 174 nonsmokers. Multivariate analysis techniques were used assess status after controlling for effects age gender. Cigarette was associated with nonspecific increase leukocyte count involving all major types (smokers: 8.50 +/- 0.15 versus nonsmokers: 7.33 0.12 cells/mm3; p less than or equal 0.0001). In addition, had selective CD4+ cells (helper-inducer cells) compared nonsmokers (55.3 0.8 52.2 0.6% lymphoid cells; = 0.002), resulting statistically significant CD4+/CD8+ (helper/suppressor) ratio (2.42 0.1 2.13 0.16; 0.02). There no difference between level CD3+ (total cells: 76.8 0.7 76.1 0.5; 0.5), CD8+ (suppressor-cytotoxic 25.7 27.0 0.5%; 0.1), CD19+ (B (10.7 0.4 10.0 0.3%; 0.2), CD14+ (monocytes) (18.0 0.6 17.0 0.4%; (14.5 0.5 14.0 0.4).(ABSTRACT TRUNCATED AT 250 WORDS)