Nonhuman Primate Diseases of Relevance in Drug Development and their Impact on the Interpretation of Study Findings

摘要: Abstract Despite recent advances in husbandry practices to control infectious diseases, a number of microbial agents continue impact animal health and research colonies. Such diseases may have an adverse on drug developmental programs during the conduct studies or confound interpretation study results. This chapter discusses common primary opportunistic that affect nonhuman primates (NHPs). Though it is not possible eliminate all NHP pathogens, well-controlled disease surveillance among facilities can assist intelligent experimental design accurate findings. particularly challenging because macaques, most genus NHPs used discovery development, increasingly been imported from countries are enzootic for such as Plasmodium spp., regions with higher incidences human measles tuberculosis. These pathogens indigenous colony potentially cause effect outcomes zoonotic risk.