Immunosuppression by Metastatic Tumors
作者： Kenneth W. Brunson , Ronald H. Goldfarb
DOI: 10.1007/978-94-009-2530-4_18
关键词:
摘要: The role of the immune response in preventing or limiting tumor growth as well affecting outcome metastases has long been debated among cancer biologists. A general consensus emerged which depicts major components system are involved surveillance and immunologic mechanisms cell killing to be cell-mediated: T-cell mediated cytotoxicity, macrophage cytotoxicity (including antibody-dependent cell-mediated ADCC, may involve certain other populations) natural killer (NK) cells (2, 4, 6, 29). All too obviously, these not always completely effective controlling development, progressive outgrowth metastasis cells. Cancer circumvent control by various ‘escape’ mechanisms, such antigenic modulation, immunologically ‘privileged’ sites, production excess antigen antigen-antibody complexes ‘blocking factors’), immunosuppression.
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