Prefabrication of a functional bone graft with a pedicled periosteal flap as an in vivo bioreactor.
作者： Ru-Lin Huang , Mathias Tremp , Chia-Kang Ho , Yangbai Sun , Kai Liu
DOI: 10.1038/S41598-017-17452-5
关键词:
摘要: The in vivo bioreactor principle, which focuses on using the body as a living to cultivate stem cells, bioscaffolds, and growth factors leveraging body's self-regenerative capacity regenerate new tissue, has been considered potential approach for bone defect reconstruction. histological characteristics of periosteum allow it possess remarkable induce remodeling, making suitable an strategy graft prefabrication. present study was designed prefabricate vascularized grafts pedicled periosteal flaps decellularized matrix (DBM) scaffolds rabbit model. muscular pouches created femoral muscle were acted control. Our results revealed that both flap group pouch induced tissue formation DBM surface at 8 16 weeks postoperatively. However, micro-computed tomography (microCT) scanning, biomechanical, histomorphometric findings indicated from showed larger mass, faster rates, higher vascular density, stronger biomechanical properties than group. We suggest is promising functional
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