Drug-protein conjugates--IV. The effect of acute renal failure on the disposition of [14C]captopril in the rat.

作者: John H.K. Yeung , Alasdair M. Breckenridge , B. Kevin Park

DOI: 10.1016/0006-2952(83)90003-5

关键词:

摘要: Abstract The effect of acute renal failure (ARF) on the metabolism and covalent binding to plasma proteins (PP) [ 14 C]captopril ([ C]CP) was investigated in Wistar rat vivo vitro using human plasma. In rat, ARF induced by parenteral administration glycerol. Glycerol-induced markedly reduced excretion C]CP, major route elimination drug control rats, but did not alter clearance C]CP. However, there a significant increase concentrations C]CP mixed disulphides with glutathione, cysteine PP. disulphide formation result an concentration radioactivity lung, liver, kidney, spleen or bile. Thus, rats excreted 9.64 ± 4.24% dose into bile 3 hr while 7.14 2.46%. , reacted rapidly form endogenous thiols With uraemic plasma, decrease amount covalently bound PP from both man rat.

参考文章(26)
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
TORU KOMAI, TOSHIHIKO IKEDA, KENJI KAWAI, EMI KAMEYAMA, HIDEYO SHINDO, IN VITRO STUDIES ON THE METABOLIC PATHWAY OF SQ 14225 (CAPTOPRIL) AND MECHANISM OF MIXED DISULFIDE FORMATION Journal of pharmacobio-dynamics. ,vol. 4, pp. 677- 684 ,(1981) , 10.1248/BPB1978.4.677
Michael H. Malloy, David K. Rassin, Gerald E. Gaull, A method for measurement of free and bound plasma cyst(e)ine. Analytical Biochemistry. ,vol. 113, pp. 407- 415 ,(1981) , 10.1016/0003-2697(81)90095-6
G. Thiel, D.R. Wilson, M.L. Arce, D.E. Oken, Glycerol Induced Hemoglobinuric Acute Renal Failure in the Rat Nephron. ,vol. 4, pp. 276- 297 ,(1967) , 10.1159/000179588
J. Fabre, L. Balant, Renal Failure, Drug Pharmacokinetics and Drug Action Clinical Pharmacokinectics. ,vol. 1, pp. 99- 120 ,(1976) , 10.2165/00003088-197601020-00002
A.B Atkinson, J.I.S Robertson, CAPTOPRIL IN THE TREATMENT OF CLINICAL HYPERTENSION AND CARDIAC FAILURE The Lancet. ,vol. 314, pp. 836- 839 ,(1979) , 10.1016/S0140-6736(79)92186-X
B. H. Migdalof, S. M. Singhvi, K. J. Kripalani, Thin-Layer Radiochromatographic Determination of Captopril (SQ 14,225) and its Disulfide Dimer Metabolite in Blood Journal of Liquid Chromatography & Related Technologies. ,vol. 3, pp. 857- 865 ,(1980) , 10.1080/01483918008060197
P. Van Brummelen, R. Willemze, W.D. Tan, J. Thompson, FranzW. Amann, FritzR. Bühler, Dieter Conen, Felix Brunner, Rudolf Ritz, Brunno Speck, Captopril-associated agranulocytosis. The Lancet. ,vol. 315, pp. 150- ,(1980) , 10.1016/S0140-6736(80)90629-7
J.D. Sun, J.G. Dent, A new method for measuring covalent binding of chemicals to cellular macromolecules. Chemico-Biological Interactions. ,vol. 32, pp. 41- 61 ,(1980) , 10.1016/0009-2797(80)90067-8
Keith K. Wong, Shih-jung Lan, Bruce H. Migdalof, In vitro biotransformations of [14C]captopril in the blood of rats, dogs and humans Biochemical Pharmacology. ,vol. 30, pp. 2643- 2650 ,(1981) , 10.1016/0006-2952(81)90532-3