Human Leukocyte Antigen Genotypes and Trial of Desensitization in Patients With Oxcarbazepine-Induced Skin Rash: A Pilot Study

摘要: Abstract Background Skin rash associated with specific antiepileptic drugs occurs not infrequently and it usually necessitates discontinuation of the causative drugs. An alternative strategy is to desensitize individual offending drug. We checked human leukocyte antigen genotypes conducted a pilot study investigate usefulness safety desensitization in pediatric patients skin oxcarbazepine. Methods enrolled 19 epilepsy who had discontinued oxcarbazepine because despite an initial good response then became refractory other along paroxysmal kinesigenic dyskinesia similar situation. High-resolution HLA-A -B genotyping was performed genetic risk. The began 0.1 mg daily reaching 120 mg on thirty-first day. Thereafter, dose increased at rate 12 mg/day. Results Nineteen completed protocol target dosage over 2-5 months. Five developed itching erythema during desensitization, but symptoms disappeared after withholding increment transiently. There were no relevant aromatic drug–induced severe hypersensitivity reactions. seizure frequency reduced less than baseline 18 individuals. Conclusion This demonstrated 95% efficacy, including 42% seizure-free favorable tolerability intractable one patient dyskinesia. Screening for sensitive types exclusion reactions should precede desensitization.