Birth characteristics and the risk of childhood rhabdomyosarcoma based on histological subtype

摘要: Little is known about risk factors for childhood rhabdomyosarcoma (RMS) and the histology-specific details are rare. Case–control studies formed by linking cancer birth registries of California, Minnesota, New York, Texas Washington, which included 583 RMS cases (363 embryonal 85 alveolar RMS) 57 966 randomly selected control subjects, were analysed using logistic regression. The associations (overall, based on or histology) with weight across five 500 g categories (from 2000 to 4500 g) examined normal (2500–3999 g) as a reference. Large (>90th percentile) small (<10th size gestational age calculated distributions in controls similarly examined. High increased overall. Each increase (odds ratio (OR)=1.27, 95% confidence interval (CI)=1.14–1.42) overall (OR=1.18, CI=1.09–1.29). also significantly (OR=1.42, CI=1.03–1.96). These data suggest positive association between accelerated utero growth RMS, but not RMS. results warrant cautious interpretation owing number cases.