Estrogen fails to facilitate resuscitation from ventricular fibrillation in male rats.

摘要: Administration of 17β-estradiol has been shown to exert myocardial protective effects in hemorrhagic shock. We hypothesized that similar could help improve resuscitation from cardiac arrest. Three series 18, 40, and 12 rats each, underwent ventricular fibrillation for 8 minutes followed by chest compression delivery electrical shocks. In series-1, were randomized 1:1 receive a bolus dose (1 mg/kg) or 0.9% NaCl before compression; series-2, 1:1:1:1 continuous infusion solution designed attain plasma level 10(0), 10(2), 10(4) nM during series-3, 10(2) compression, providing inotropic support the post-resuscitation interval using dobutamine infusion. failed facilitate each 3 series. series-1 resuscitability short-term survival was reduced groups attaining statistical significance series-2 when three combined (p = 0.035). all resuscitated survived 180 aided which partially reversed dysfunction but without additional benefits on function group. The present study beneficial effect arrest raised possibility detrimental compromising initial subsequent male rat model closed resuscitation.