Genetic determinants of response to cardiovascular drugs.
作者： Quinn S. Wells , Jessica T. Delaney , Dan M. Roden
DOI: 10.1097/HCO.0B013E32835220E3
关键词:
摘要: PURPOSE OF REVIEW To survey genetic variation contributing to variable responsiveness and toxicity important cardiovascular drugs highlight recent developments in the field of pharmacogenomics personalized medicine. RECENT FINDINGS Previously recognized pharmacogenomic associations with drug efficacy have been further validated (e.g. clopidogrel warfarin) shown influence clinically outcomes. The clinical significance variants modulating SLCO1B1 simvastatin) has also confirmed. contribution other classes drugs, such as beta-blockers, is becoming increasingly recognized. Prospective trials testing whether use genomic information improves care are underway. Guidance based on most well-established findings appeared prescribing labeling early stages being implemented into routine care. SUMMARY Clinically gene that modulate continue be discovered validated. Early steps underway translate these discoveries
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