Modulation of mononuclear phagocyte function by intravenous gamma-globulin.

摘要: To assess the effects on mononuclear phagocyte function of i.v. gamma-globulin treatment in idiopathic thrombocytopenic purpura, we examined vivo and vitro 11 patients before after therapy. All patients, both splenectomized non-splenectomized, demonstrated a prolongation clearance autologous IgG-sensitized erythrocytes (p less than 0.01). Concurrent assessment blood monocyte showed decreased erythrocyte (EA) rosette formation (mean +/- SD: 31.6% 8.2 vs 24.5% 9.5; p 0.03) affinity Fc receptor-specific IgG oligomer binding (9.9 16.3 1.8 2.1 X 10(8) M-1; 0.008), but no consistent change estimate maximum number sites. Phagocytosis two different EA probes was (EhuA:0.49 0.26 0.25 0.14 erythrocyte/monocyte/hr; 0.02, EoxA: 1.76 0.66 1.27 0.67 erythrocyte/monocyte/hr, 0.05). The system significantly correlated with association constant for (r = 0.98, These data demonstrate that infusions induce alterations are not dependent presence serum containing infusate. apparent receptor rather may reflect an altered population properties.