Regulation of ICAM-1 in Cells of the Monocyte/Macrophage System in Microgravity
作者： Katrin Paulsen , Svantje Tauber , Claudia Dumrese , Gesine Bradacs , Dana M. Simmet
DOI: 10.1155/2015/538786
关键词:
摘要: Cells of the immune system are highly sensitive to altered gravity, and monocyte as well macrophage function is proven be impaired under microgravity conditions. In our study, we investigated surface expression ICAM-1 protein mRNA in cells monocyte/macrophage during clinostat, parabolic flight, sounding rocket, orbital experiments. murine BV-2 microglial cells, detected a downregulation clinorotation experiments rapid reversible phase flight contrast, increased macrophage-like differentiated human U937 flights long-term provided by 2D clinostat or SIMBOX/Shenzhou-8 mission. nondifferentiated no effect on could observed We conclude that disturbed consequence modulation system, which turn have strong impact interaction with T lymphocytes cell migration. Thus, can considered rapid-reacting sustained gravity-regulated molecule mammalian cells.
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