Quality control materials for pharmacogenomic testing in the clinic.

摘要: Pharmacogenomics has significantly added to our understanding of drug responses in clinical pharmacology, changing the paradigm treatment decisions. Interrogations both inherited and somatic variations for therapeutic purposes are increasingly being adopted clinics, where quality control (QC) materials required. However, many pharmacogenomic tests, acquisition well-characterized QC is often difficult or impossible. In this review, several sources appropriate therapy-associated genetic testing discussed. Among them, novel methods producing renewable controls that resemble patient samples highlighted. Owing technological complexity, more efforts needed develop proper next-generation sequencing-based assay.