9 Transcriptomics of Industrial Filamentous Fungi: A New View on Regulation, Physiology, and Application

作者: Benjamin M. Nitsche , Vera Meyer

DOI: 10.1007/978-3-642-45218-5_9

关键词:

摘要: The filamentous fungi Aspergillus niger, A. oryzae, Penicillium chrysogenum and Trichoderma reesei represent an important group of industrial production hosts with unique properties in relation to metabolite protein production. They serve as a major resource for applications processes areas such food, feed, antibiotics, biofuel chemical With the newly emerged ‘-omics’ era, system-wide insights into genomic repertoire physiology are possible, last few years have therefore witnessed great advances understanding their metabolic potential. This review summarizes transcriptomics recently gained gene regulation these cell factories. New concepts ideas derived from this perspective that aim engineer fungal metabolism more sustainable bioprocesses novel products highlighted discussed.

参考文章(136)
Arman Vinck, Charissa de Bekker, Adam Ossin, Robin A. Ohm, Ronald P. de Vries, Han A. B. Wösten, Heterogenic expression of genes encoding secreted proteins at the periphery of Aspergillus niger colonies Environmental Microbiology. ,vol. 13, pp. 216- 225 ,(2011) , 10.1111/J.1462-2920.2010.02322.X
Mikko Arvas, Tiina Pakula, Karin Lanthaler, Markku Saloheimo, Mari Valkonen, Tapani Suortti, Geoff Robson, Merja Penttilä, Common features and interesting differences in transcriptional responses to secretion stress in the fungi Trichoderma reesei and Saccharomyces cerevisiae. BMC Genomics. ,vol. 7, pp. 32- 32 ,(2006) , 10.1186/1471-2164-7-32
Stephan J. A. Hesse, George J. G Ruijter, Cor Dijkema, Jaap Visser, Intracellular pH homeostasis in the filamentous fungus Aspergillus niger FEBS Journal. ,vol. 269, pp. 3485- 3494 ,(2002) , 10.1046/J.1432-1033.2002.03042.X
G. J. G. Ruijter, C. P. Kubicek, J. Visser, Production of Organic Acids by Fungi Industrial Applications. pp. 213- 230 ,(2002) , 10.1007/978-3-662-10378-4_10
Natalia Semova, Reginald Storms, Tricia John, Pascale Gaudet, Peter Ulycznyj, Xiang Min, Jian Sun, Greg Butler, Adrian Tsang, Generation, annotation, and analysis of an extensive Aspergillus niger EST collection BMC Microbiology. ,vol. 6, pp. 7- 7 ,(2006) , 10.1186/1471-2180-6-7
Arman Vinck, Maarten Terlou, Wiebe R. Pestman, Edwin P. Martens, Arthur F. Ram, Cees A. M. J. J. van den Hondel, Han A. B. Wösten, Hyphal differentiation in the exploring mycelium of Aspergillus niger Molecular Microbiology. ,vol. 58, pp. 693- 699 ,(2005) , 10.1111/J.1365-2958.2005.04869.X
K. Romisch, Surfing the Sec61 channel: bidirectional protein translocation across the ER membrane Journal of Cell Science. ,vol. 112, pp. 4185- 4191 ,(1999) , 10.1242/JCS.112.23.4185
Vera Meyer, Robbert A. Damveld, Mark Arentshorst, Ulf Stahl, Cees A. M. J. J. van den Hondel, Arthur F. J. Ram, Survival in the presence of antifungals: genome-wide expression profiling of Aspergillus niger in response to sublethal concentrations of caspofungin and fenpropimorph. Journal of Biological Chemistry. ,vol. 282, pp. 32935- 32948 ,(2007) , 10.1074/JBC.M705856200
Levente Karaffa, Christian P. Kubicek, Aspergillus niger citric acid accumulation: do we understand this well working black box? Applied Microbiology and Biotechnology. ,vol. 61, pp. 189- 196 ,(2003) , 10.1007/S00253-002-1201-7