Synergic chemoprevention with dietary carbohydrate restriction and supplementation of AMPK-activating phytochemicals: the role of SIRT1
作者： Jong Doo Lee , Min-Ah Choi , Simon Weonsang Ro , Woo Ick Yang , Arthur E.H. Cho
DOI: 10.1097/CEJ.0000000000000141
关键词:
摘要: Calorie restriction or a low-carbohydrate diet (LCD) can increase life span in normal cells while inhibiting carcinogenesis. Various phytochemicals also have calorie restriction-mimetic anticancer properties. We investigated whether an isocaloric carbohydrate-restriction and AMP-activated protein kinase (AMPK)-activating induce synergic tumor suppression. used mixture of AMPK-activating phytochemical extracts including curcumin, quercetin, catechins, resveratrol. Survival analysis was carried out B16F10 melanoma model fed control (62.14% kcal carbohydrate, 24.65% kcal 13.2% kcal fat), with multiple (MP), LCD (16.5, 55.2, 28.3% kcal, respectively), (LCDmp), moderate-carbohydrate (MCD, 31.9, 62.4, 5.7% kcal, MCD (MCDmp). Compared the group, MP, LCD, intervention did not produce survival benefit, but LCDmp (22.80±1.58 vs. 28.00±1.64 days, P=0.040) MCDmp (23.80±1.08 30.13±2.29 P=0.008) increased median time significantly. Suppression IGF-1R/PI3K/Akt/mTOR signaling, activation AMPK/SIRT1/LKB1pathway, NF-κB suppression were critical tumor-suppression mechanisms. In addition, SIRT1 suppressed proliferation A375SM under low-glucose condition. Alterations histone methylation within Pten FoxO3a observed after intervention. transgenic liver cancer developed by hydrodynamic transfection HrasG12V shp53, interventions induced significant cancer-prevention effects. Microarray showed that PPARα decreased IL-6 hepatocytes conclusion, natural agents synergistic acts as suppressor
sci-hub.se 参考文章(54)
R. J. Colman, R. M. Anderson, S. C. Johnson, E. K. Kastman, K. J. Kosmatka, T. M. Beasley, D. B. Allison, C. Cruzen, H. A. Simmons, J. W. Kemnitz, R. Weindruch, Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys Science. ,vol. 325, pp. 201- 204 ,(2009) , 10.1126/SCIENCE.1173635
Q. Sun, X. Chen, J. Ma, H. Peng, F. Wang, X. Zha, Y. Wang, Y. Jing, H. Yang, R. Chen, L. Chang, Y. Zhang, J. Goto, H. Onda, T. Chen, M.-R. Wang, Y. Lu, H. You, D. Kwiatkowski, H. Zhang, Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth Proceedings of the National Academy of Sciences of the United States of America. ,vol. 108, pp. 4129- 4134 ,(2011) , 10.1073/PNAS.1014769108
Eric L. Greer, Philip R. Oskoui, Max R. Banko, Jay M. Maniar, Melanie P. Gygi, Steven P. Gygi, Anne Brunet, The Energy Sensor AMP-activated Protein Kinase Directly Regulates the Mammalian FOXO3 Transcription Factor Journal of Biological Chemistry. ,vol. 282, pp. 30107- 30119 ,(2007) , 10.1074/JBC.M705325200
A. J. Levine, A. M. Puzio-Kuter, The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes Science. ,vol. 330, pp. 1340- 1344 ,(2010) , 10.1126/SCIENCE.1193494
Alexander Konson, Sunila Pradeep, Rony Seger, Phosphomimetic mutants of pigment epithelium-derived factor with enhanced antiangiogenic activity as potent anticancer agents. Cancer Research. ,vol. 70, pp. 6247- 6257 ,(2010) , 10.1158/0008-5472.CAN-10-0434
Carmit Levy, Mehdi Khaled, David E. Fisher, MITF: master regulator of melanocyte development and melanoma oncogene Trends in Molecular Medicine. ,vol. 12, pp. 406- 414 ,(2006) , 10.1016/J.MOLMED.2006.07.008
D R Calnan, A Brunet, The FoxO code Oncogene. ,vol. 27, pp. 2276- 2288 ,(2008) , 10.1038/ONC.2008.21
Javier A. Menendez, Cristina Oliveras-Ferraros, Sílvia Cufí, BRUNA COROMINAS-FAJA, Jorge Joven, Begoña Martin-Castillo, Alejandro Vazquez-Martin, Metformin is synthetically lethal with glucose withdrawal in cancer cells Cell Cycle. ,vol. 11, pp. 2782- 2792 ,(2012) , 10.4161/CC.20948
Luigi Ricciardiello, Franco Bazzoli, Vincenzo Fogliano, Phytochemicals and colorectal cancer prevention--myth or reality? Nature Reviews Gastroenterology & Hepatology. ,vol. 8, pp. 592- 596 ,(2011) , 10.1038/NRGASTRO.2011.149
Hengbin Wang, Ru Cao, Li Xia, Hediye Erdjument-Bromage, Christoph Borchers, Paul Tempst, Yi Zhang, Purification and Functional Characterization of a Histone H3-Lysine 4-Specific Methyltransferase Molecular Cell. ,vol. 8, pp. 1207- 1217 ,(2001) , 10.1016/S1097-2765(01)00405-1