Cell Cycle Control by the IGF-1 Receptor and Its Ligands
作者： Renato Baserga , Pierluigi Porcu , Michele Rubini , Christian Sell
DOI: 10.1007/978-1-4615-2988-0_11
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摘要: The interaction of the IGF-1 receptor with its ligands (IGF-1, IGF-II and insulin at supraphysiological concentrations) plays a major role in normal development control both abnormal growth (for reviews, see Werner et al., 1991 Lowe, 1991). importance is especially supported by seminal experiments Efstratiadis co-workers (DeChiara 1990, personal communication). These investigators have shown that targeted disruption gene results progeny, which, birth, has body weight 70% wild type litter mates. When genes are disrupted homologous recombination, homozygous mutant embryos birth only 30% Thus, it can be stated activation (IGF-1 or IGF-II) accounts for embryonal murine growth.
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