History of Embryo Stem Cells

摘要: This chapter gives a factual account of work on embryo stem cells since its inception in the early 1960s. The systematic analysis began 1960s at Glasgow University. Studies maturation human oocytes led to vitro fertilization (IVF), preimplantation genetic diagnosis, and growth for therapeutic purpose, which was based works Pincus Saunders. Coincidentally, mammals increasing number following initial 1890 by Heape. Experimental studies 1940 Nicholas Hall, 1952 Seidel, assessed developmental capacity each two-cell blastomere rabbit embryos. At same time, Beatty Fischberg inactivated second metaphase spindle warming ovulated mouse vivo produce triploid embryos after fertilization. first IVF baby delivered 1978—after considerable effort—signaling imminence alleviating infertility, introducing using purposes. Two lines research developed laboratories are attempts use blastocyst postimplantation fetuses as sources grafting into sick recipients.