Persistent Neural Membrane Protein Misregulation Following Neurotoxicant Exposure

摘要: Abstract : Cellular, molecular and behavioral experiments were conducted in rats to determine the basis of a widespread chronic pain that is frequently reported veterans 1991 Gulf War. Behavioral studies examined whether exposure insecticides (chlorpyrifos, permethrin) nerve gas prophylactic (pyridostigmine bromide) could produce delayed persistent myalgia arthralgia. Following 60 day these War chemicals, we observed an increase resting behaviors persisted for 12 weeks after exposures had ceased. Muscle vascular nociceptive neurons harvested from animals, at 8 post-exposure, exhibited broad alterations physiology Kv ion channels (Kv7 other KDR channel proteins) Nav1.9 consistent with increased cellular excitability week observation period. An imbalance between Kv7 prove be condition sourced vulnerable subset muscle nociceptors. Because are widely expressed throughout nervous system, maladaptations their contribute development variety sensory, motor, cognitive autonomic symptoms associated Illness.