The Role of Stem Cells in the Etiology and Pathophysiology of Endometriosis

摘要: Human endometrium is a dynamic organ that normally undergoes repetitive cyclic regeneration. To enable this rapid regeneration, it not surprising the contains reservoir of progenitor stem cells. However, pool cells allows growth also for unrestrained can reach beyond endometrium. In review, we will address role in endometriosis. Recent characterization cell populations within human has opened possibility understanding their physiologic as well pathologic roles. While are critical to regeneration healthy endometrium, have shown both endometrium-derived and bone marrow-derived migrate ectopic sites contribute development Furthermore, endometriosis interferes with normal trafficking uterus necessary endometrial repair. Altered mobility engraftment characterize disease.