Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value

摘要: The diagnosis of rheumatoid arthritis (RA) is primarily based on clinical symptoms, so it often difficult to diagnose RA in very early stages the disease. A disease-specific autoantibody that could be used as a serological marker would therefore useful. Most autoimmune diseases are characterized by polyclonal B-cell response targeting multiple autoantigens. These immune responses not specific for single In this review, most important autoantibody/autoantigen systems associated with described and their utility diagnostic prognostic tool, including specificity, sensitivity practical application, discussed. We conclude that, at present, antibody directed citrullinated antigens has valuable potential RA.