Directed (R)- or (S)-Selective Dynamic Kinetic Enzymatic Hydrolysis of 1,2,3,4-Tetrahydroisoquinoline-1-carboxylic Esters
作者： Tihamér A Paál , Arto Liljeblad , Liisa T Kanerva , Enikő Forró , Ferenc Fülöp
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摘要: The first synthesis of both enantiomers 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid was accomplished through dynamic kinetic resolution in procedures based on CAL-B- or subtilisin Carlsberg-catalysed enantioselective hydrolysis the corresponding ethyl esters aqueous NH4OAc buffer at pH 8.5. products were obtained with high enantiopurity (92–93 % ee) good yields (85–92 %). (R)-1,2,3,4-Tetrahydroisoquinoline-1-carboxylic (98 % ee) and yield (85 %) a CAL-B-catalysed process, under similar conditions.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
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