Effects of 6-hydroxydopamine on catecholamine containing neurones in the rat brain.

摘要: After the intraventricular injection of 6-hydroxydopamine (6-OHDA), there was a long lasting reduction in brain concentrations noradrenaline (NA) and dopamine (DA). The concentration NA affected by lower doses 6-OHDA than were required to deplete DA. A high dose which depleted DA 81 per cent 66 respectively, had no significant effect on 5-hydroxytryptamine (5-HT) or γ-aminobutyric acid (GABA). fall catecholamines accompanied activities tyrosine hydroxylase DOPA decarboxylase hypothalamus striatum, areas are rich catecholamine containing nerve endings. There was, however, consistent catechol-O-methyl transferase monamine oxidase activity these regions. initial accumulation [3H]NA into slices striatum markedly reduced 22–30 days after treatment. These results with evidence peripheral sympathetic nervous system that causes selective destruction adrenergic endings suggest this compound may have similar destructive neurones CNS.