The Second National Acute Spinal Cord Injury Study.

摘要: In 1990, the Second National Acute Spinal Cord Injury Study reported that high-dosage methylprednisolone improves neurologic recovery in spinal-injured humans. The study showed patients who received drug within 8 hr after injury improved, whereas those later did not. significantly increased even severely injured were admitted with no motor or sensory function below lesion, contradicting a long-held dogma such would not recover. Some researchers, however, have questioned stratification of patient population, use summed change scores, and absence functional assessments. by severity treatment time was planned priori based on objective criteria. Detailed analyses revealed differences between groups attributable to randomization. While multivariate scores used, conclusions corroborated other analytical approaches rely scores. For example, more than doubled probability convert from quadriplegia paraplegia quadriparesis paraparesis, analgesia hypalgesia, anesthesia hypesthesia. also improved lumbosacral segments, indicating beneficial effects limited segments close lesion site. affect mortality morbidity. strongly suggests has significant human spinal cord injury, these occur only when is given hr, it helps severe injuries. These important implications for care research.