Recent Progress in Blood–Brain Barrier and Blood–CSF Barrier Transport Research: Pharmaceutical Relevance for Drug Delivery to the Brain
作者： Masanori Tachikawa , Yasuo Uchida , Sumio Ohtsuki , Tetsuya Terasaki
DOI: 10.1007/978-1-4614-9105-7_2
关键词:
摘要: The blood–brain barrier (BBB) and the blood–CSF (BCSFB) possess multiple transport systems for endogenous xenobiotic compounds to maintain functional homeostasis in central nervous system (CNS). Accumulating evidence on has provided a basis development of rational strategies drug delivery targeting CNS. blood-to-brain influx at BBB have great potential CNS-acting brain. brain-to-blood efflux including ATP-binding cassette transporters hinder penetration Efflux BCSFB also play an important role cerebral clearance neurotoxic which are associated with disorders Several drugs influence brain barriers. This chapter focuses current state knowledge concerning roles BCSFB, implications these CNS delivery.
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