Comparative Aspects of Nucleotide and Amino-acid Metabolism in Toxoplasma gondii and other Apicomplexa

摘要: Publisher Summary Nucleotides and amino acids are of fundamental importance in the replication development Toxoplasma gondii other apicomplexan parasites. particular essential for DNA transcription RNA rapidly dividing stages. also providing cellular energy sources (ATP GTP), involved numerous metabolic roles. either synthesized from small molecules acids, or they acquired via salvage pathways preformed host-derived nucleobases nucleosides. The parasites considered this chapter, gondii, Plasmodium falciparum, Cryptosporidium parvum, important pathogens humans that cause significant morbidity mortality. Notably, current treatment strategies human infections caused by T. P. falciparum based on blocking accumulation nucleotides. This validated approach to chemotherapy highlights significance further research dissect details nucleotide metabolism Apicomplexa as well potential lead new treatments.