Tandem α‐Alkylation/Asymmetric Transfer Hydrogenation of Acetophenones with Primary Alcohols
作者： Oleksandr O. Kovalenko , Helena Lundberg , Dennis Hübner , Hans Adolfsson
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摘要: A tandem -alkylation/asymmetric transfer hydrogenation of acetophenones with primary alcohols, mediated by a single ruthenium catalyst, is described. Under optimized reaction conditions and use [Ru(p-cymene)Cl-2](2) in combination an amino acid hydroxyamide ligand, the chiral secondary alcohol products were isolated moderate yields to good enantiomeric excess (up 89% ee).
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