NSAIDs and cardiovascular drugs in neurodegenerative and cerebrovascular diseases

摘要: textabstractNeurodegenerative and cerebrovascular diseases are frequent in elderly populations and comprise primarily of dementia (mainly Alzheimer disease (AD)), Parkinson disease (PD) stroke. The prevalence these neurological disorders rises with older age. From 55 years to 90 above, the increases from less than 1% over 40%.1-3 For PD, same age range from less than 0.5% more 4%,4,5 for stroke approximately to nearly 10%.6,7 Similar age-related patterns observed incidence figures.8-11 In the Netherlands, population persons 65 is expected increase from 2.4 million 2007 3.9 2050.12 At a global level, 2 billion persons above by 2050.13 As consequence aging population the will increase accordingly. Moreover, all constitute highly disabling diseases, appreciable impact on quality-of-life at patient but also on society, both economically socially.12,14-17 Currently, there no effective cure for AD18, PD19 or consequences stroke.20 Hence, identification determinants of these development preventive strategies paramount importance. This search is, part, directed currently available drugs which target established risk factors disease, that have, vivo vitro studies, shown interfere specific elements supposed pathogenic pathway disease. Two drug groups commonly used interest, namely nonsteroidal anti-inflammatory (NSAIDs) cardiovascular medication. The general objective this thesis was study role as of neurodegenerative diseases.