The Effect of Branching (Star Architecture) on Poly(d,l-lactide) (PDLLA) Degradation and Drug Delivery

作者: Jason Burke , Roberto Donno , Richard d’Arcy , Sarah Cartmell , Nicola Tirelli

DOI: 10.1021/ACS.BIOMAC.6B01524

关键词:

摘要: This study focuses on the comparative evaluation of star (branched) and linear poly(l,d-lactic acid) (PDLLA) as degradable materials employed in controlled release. The polymers were prepared via ring-opening polymerization initiated by decanol (linear), pentaerythritol (4-armed star) dipentaerythritol (6-armed star), processed both form films nanoparticles. Independent length or number their arms, degrade slower than polymers, possibly through a surface (vs bulk) mechanism. Further, release model drug (atorvastatin) followed zero-order-like kinetics for branched first-order PDLLA. Using NHOst osteoblastic cells, devoid any significant toxicity released atorvastatin bioavailable form; cell adhesion was considerably lower polymer films, from nanoparticles appeared to be beneficial avoid overdosing.

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