Experimental crystal nephropathy (one year study in the pig).

摘要: An acute crystal nephropathy was produced in pigs by feeding a mixture of guanine and allopurinol. The pathogenesis the lesion studied serial histology renal function tests over 12 months. Tubular blockage crystals erosion basement membrane an accompanying interstitial nephritis. degeneration around mass transferred to interstitium. Despite rapid subsequent disappearance these nephritis still evident nine months later. early return near normal not sustained beyond It shown that even brief periods intratubular deposition caused irreversible changes, resulting eventually reduction kidney size, nephron population function.