Rewiring of transcriptional networks as a major event leading to the diversity of asexual multicellularity in fungi

摘要: Abstract Complex multicellularity (CM) is characterized by the generation of three-dimensional structures that follow a genetically controlled program. CM emerged at least five times in evolution, one them fungi. There are two types programs fungi, leading, respectively, to formation sexual or asexual spores. Asexual spores foment spread mycoses, as they main vehicle for dispersion. In spite this key dependence, there great morphological diversity multicellular To advance understanding mechanisms control initiation and progression how can lead such remarkable diversification, we studied 503 fungal proteomes, representing all phyla subphyla, most known classes. Conservation analyses 33 regulators development suggest stepwise emergence transcription factors. While velvet proteins constitute ancient systems, central regulator BrlA late evolution (with class eurotiomycetes). Some factors, MoConX4, seem be species-specific. These observations transcriptional rewire networks. This process could reach species level, resulting vast morphologies. One-sentence summary A study production