Engineering of Cell Proliferation Via Myc Modulation

摘要: The use of metabolic engineering for the enhancement and control cell proliferation is a rapidly developing field in biotechnology. Great research interest has been directed towards development apoptosis controlled lines with high density, regulated proliferation, resistance, easy adaptation into serum free cultures. These are some desirable characteristics cost effective production biopharmaceuticals, mainly because genetically modified can afford greater efficiency control. Some strategies employed by management include external factors culture environment, suppression growth inhibitors, over-expression important regulators pathways, such as genes. c-myc prime candidate to achieve these objectives. In its role transcription factor Myc regulate an extensive array biological activities modulating expression large number genes that turn multiple downstream events. More importantly, transform cells manner consider advantages utilising unique major significance animal biotechnology