Relating glaucomatous visual field loss to retinal oxygen delivery and metabolism.
作者： Ahmad A Aref , Shervin Maleki , Ou Tan , David Huang , Rohit Varma
DOI: 10.1111/AOS.14120
关键词:
摘要: PURPOSE To test the hypothesis that visual field (VF) loss is associated with decreased retinal blood flow, oxygen delivery and metabolism, increased extraction fraction (OEF) in glaucomatous individuals. METHODS Glaucomatous subjects underwent automated perimetry, dual wavelength scanning laser ophthalmoscopy Doppler optical coherence tomography imaging order to measure mean deviation, central arterial venous diameter equivalents (CRAE CRVE), saturation levels total flow (TRBF), respectively. Retinal delivery, metabolism were derived from measurements of flow. RESULTS Twenty eyes 14 included study. Mean deviation was on average -13.76 ± 8.70 dB. CRAE CRVE 126 ± 28 191 ± 35 μm, TRBF 34.3 ± 11.7 μl/min 6.5 ± 2.6 μl O2 /min, 2.1 ± 0.94 μl /min 0.34 ± 0.15, Visual reduced CRVE, OEF. CONCLUSION Combined individuals suggest VF impaired augmented
elsevier.com
sci-hub.se 参考文章(41)
Georg Michelson, Mateusz Scibor, Intravascular oxygen saturation in retinal vessels in normal subjects and open-angle glaucoma subjects Acta Ophthalmologica Scandinavica. ,vol. 84, pp. 289- 295 ,(2006) , 10.1111/J.1600-0420.2005.00631.X
Ou Tan, Gangjun Liu, Liu Liang, Simon S. Gao, Alex D. Pechauer, Yali Jia, David Huang, En face Doppler total retinal blood flow measurement with 70 kHz spectral optical coherence tomography Journal of Biomedical Optics. ,vol. 20, pp. 066004- 066004 ,(2015) , 10.1117/1.JBO.20.6.066004
Louis R. Pasquale, Akiko Hanyuda, Ai Ren, Michael Giovingo, Scott H. Greenstein, Clara Cousins, Thomas Patrianakos, Angelo P. Tanna, Christopher Wanderling, William Norkett, Janey L. Wiggs, Kelsey Green, Jae H. Kang, Paul A. Knepper, Nailfold Capillary Abnormalities in Primary Open-Angle Glaucoma: A Multisite Study. Investigative Ophthalmology & Visual Science. ,vol. 56, pp. 7021- 7028 ,(2015) , 10.1167/IOVS.15-17860
Olof Birna Olafsdottir, Sveinn Hakon Hardarson, Maria Soffia Gottfredsdottir, Alon Harris, Einar Stefánsson, Retinal oximetry in primary open-angle glaucoma. Investigative Ophthalmology & Visual Science. ,vol. 52, pp. 6409- 6413 ,(2011) , 10.1167/IOVS.10-6985
J.C. Parr, G.F.S. Spears, Mathematic relationships between the width of a retinal artery and the widths of its branches. American Journal of Ophthalmology. ,vol. 77, pp. 478- 483 ,(1974) , 10.1016/0002-9394(74)90458-9
L. Ramm, S. Jentsch, S. Peters, R. Augsten, M. Hammer, Investigation of blood flow regulation and oxygen saturation of the retinal vessels in primary open-angle glaucoma Graefes Archive for Clinical and Experimental Ophthalmology. ,vol. 252, pp. 1803- 1810 ,(2014) , 10.1007/S00417-014-2766-4
Vicki Chrysostomou, Fatemeh Rezania, Ian A Trounce, Jonathan G Crowston, Oxidative stress and mitochondrial dysfunction in glaucoma Current Opinion in Pharmacology. ,vol. 13, pp. 12- 15 ,(2013) , 10.1016/J.COPH.2012.09.008
Evelien Vandewalle, L Abegão Pinto, Olof B. Olafsdottir, Eline De Clerck, Peter Stalmans, Joachim Van Calster, Thierry Zeyen, Einar Stefánsson, Ingeborg Stalmans, Oximetry in glaucoma: correlation of metabolic change with structural and functional damage. Acta Ophthalmologica. ,vol. 92, pp. 105- 110 ,(2012) , 10.1111/AOS.12011
YAO WANG, KUN XU, HONGBING ZHANG, JUNHONG ZHAO, XIUPING ZHU, YANGZHENG WANG, RENYI WU, Retinal ganglion cell death is triggered by paraptosis via reactive oxygen species production: A brief literature review presenting a novel hypothesis in glaucoma pathology Molecular Medicine Reports. ,vol. 10, pp. 1179- 1183 ,(2014) , 10.3892/MMR.2014.2346
Maiko Naka, Akiyasu Kanamori, Yasuko Tatsumi, Miyuki Fujioka, Azusa Nagai-Kusuhara, Makoto Nakamura, Akira Negi, Comparison of mean deviation with AGIS and CIGTS scores in association with structural parameters in glaucomatous eyes. Journal of Glaucoma. ,vol. 18, pp. 379- 384 ,(2009) , 10.1097/IJG.0B013E3181879E75