Berberine Ameliorates Intestinal Mucosal Barrier Damage Induced by Peritoneal Air Exposure

摘要: Abstract Berberine, an isoquinoline alkaloid derived from many medicinal plants, has been extensively used to treat various gastrointestinal diseases. In the present study, we investigated whether berberine could ameliorate intestinal mucosal barrier damage induced by peritoneal air exposure for 3 h. Peritoneal air-exposure rats received 100, 150, and 200 mg/kg orally via gavage four times before after surgery. Blood terminal ileum samples were collected 24 h The serum D-lactate levels determined using enzyme-linked immunosorbent assay (ELISA) kit. Intestinal permeability was measuring clearance of fluorescein isothiocyanate (FITC)-dextran (FD4). inflammation assessed myeloperoxidase activity. histopathology also assessed. results revealed that decreased level, FD4 clearance, Edema reduced in mucosa submucosa, Chiu's scores, indices injury, berberine-treated group. addition, exerted these protective effects a dose-dependent manner, with significant difference control group at doses 150 200 mg/kg. suggest exposure, which is linked its anti-inflammatory Berberine may be promising treatment open abdominal