Construction of a whole body blood flow model for use in positron emission tomography imaging with [15O]water.

摘要: A whole body blood flow model (WBBFM) was developed and tested using STELLA II, an icon-driven mathematical simulation software package. The WBBFM uses parallel chambers to represent gray white areas of the brain, organs such as lungs, heart (right left halves), injection site, sampling sites. Input values include organ flows, volumes, tissue:blood partition coefficients, injected activity, data acquisition times for a positron emission tomography (PET) camera. variables included function (e.g., bolus), transient variations in flow). kinetic behavior [15O]water, freely diffusible radiotracer employed PET characterize examined by WBBFM. physiologic water human emulated model's predictive value verified comparing calculated results with following properties water: diffusibility, coefficient mixing [15O]water total water. simulated Kety's autoradiographic method used estimation regional cerebral [15O]water. application cognitive activation study paradigm based on is presented its compared published literature data. With appropriate modification half-life, coefficient, amount administered radioactivity, should prove useful us tool examine kinetics other radiotracers PET.