Fullerene-based Low Toxic Nanocationite Particles (Porphyrin Adducts of Cyclohexyl Fullerene-C60) to Treat Hypoxia-induced Mitochondrial Dysfunction in Mammalian Heart Muscle

摘要: Abstract Background This is the first report on targeted delivery of fullerene-based low toxic nanocationite particles (porphyrin adducts cyclohexyl fullerene-C 60 ) to treat hypoxia-induced mitochondrial dysfunction in mammalian heart muscle. Methods The magnetic isotope effect generated by release paramagnetic 25 Mg 2+ from these nanoparticles selectively stimulates ATP overproduction oxygen-depleted cell. Results Because are membranotropic cationites, they will only overactivating cations response acidic shift. resulting changes cell energy metabolism result ∼80% recovery affected myocardium 50 ). Conclusions Pharmacokinetics and pharmacodynamics suggest their suitability for safe efficient administration either single or multi-injection (acute chronic) therapeutic schemes prevention treatment clinical conditions involving myocardial hypoxia.