Linking Essential Tremor to the Cerebellum—Animal Model Evidence

摘要: In this review, we hope to stimulate interest in animal models as opportunities understand tremor mechanisms within the cerebellar system. We begin by considering harmaline model of essential (ET), which has ET-like anatomy and pharmacology. Harmaline induces inferior olive (IO) burst fire rhythmically, recruiting rhythmic activity Purkinje cells (PCs) deep nuclei (DCN). This fostered IO hypothesis ET, postulates that factors promote excess IO, hence PC complex spike synchrony, also tremor. contrast, partial cell loss underlies ET. describe chronic is associated with tremor, such Weaver mouse, others do not show degeneration mouse. postulate terminal axonal sprouting. then discuss occurs large lesions cerebellum primates. variable frequency an ataxic related Another type likely ET mice mutations cause prolonged synaptic GABA action. probably due mistiming circuitry. final section, catalog involving neurotransmitter ion channel perturbations. Some appear be while may or mistiming. summary, offer a tentative framework for classifying action various considered potentially relevant subscribing hypotheses, relevant, Considerable further research needed elucidate models.