Une étude de la réponse des cellules B mémoires au vaccin polysaccharidique conjugué contre le méningocoque du sérogroupe C
作者： Géraldine Blanchard Rohner
DOI:
关键词:
摘要: "Neisseraia meningitidis" est une cause importante de maladies invasives chez les enfants. En Angleterre, le vaccin polysaccharidique conjugue contre serogroupe C fait partie du plan vaccination routine. Chez enfants moins d'une annee, 3 doses induisent montee des anticorps bactericides, mais qui ne persistent pas au-dela annee. Les cellules B memoires, semblent essentielles pour proteger jeunes primo-immunises comme nourrissons. Dans cette etude, j'ai evalue la persistance dans sang plasmocytes producteurs d'anticorps et memoires specifiques 12 mois a 2,3, 4 mois. resultats montrent que ces cellules, generalement non detectables, reapparaissent jour 6 (plasmocytes) ou 8 (cellules memoire) apres dose rappel conjugue. Ces donnees permettent mieux comprendre participation l'immunite memoire protection infections "N. meningitidis".
参考文章(112)
Claire V. Broome, The carrier state: Neisseria meningitidis. Journal of Antimicrobial Chemotherapy. ,vol. 18, pp. 25- 34 ,(1986) , 10.1093/JAC/18.SUPPLEMENT_A.25
M. CONNOLLY, N. NOAH, Is group C meningococcal disease increasing in Europe? A report of surveillance of meningococcal infection in Europe 1993-6 Epidemiology and Infection. ,vol. 122, pp. 41- 49 ,(1999) , 10.1017/S0950268898001848
D A Caugant, E A Høiby, P Magnus, O Scheel, T Hoel, G Bjune, E Wedege, J Eng, L O Frøholm, Asymptomatic carriage of Neisseria meningitidis in a randomly sampled population Journal of Clinical Microbiology. ,vol. 32, pp. 323- 330 ,(1994) , 10.1128/JCM.32.2.323-330.1994
Shane Crotty, Phil Felgner, Huw Davies, John Glidewell, Luis Villarreal, Rafi Ahmed, None, Cutting Edge: Long-Term B Cell Memory in Humans after Smallpox Vaccination Journal of Immunology. ,vol. 171, pp. 4969- 4973 ,(2003) , 10.4049/JIMMUNOL.171.10.4969
Wendell D. Zollinger, Brenda L. Brandt, Dennis L. Kasper, Malcolm S. Artenstein, Jeffrey L. Winkelhake, Immunochemical Similarity Between Polysaccharide Antigens of Escherichia Coli 07:K1(L):NM and Group B Neisseria Meningitidis Journal of Immunology. ,vol. 110, pp. 262- 268 ,(1973)
Maria Pihlgren, Chantal Tougne, Paola Bozzotti, Alma Fulurija, Michel A. Duchosal, Paul-Henri Lambert, Claire-Anne Siegrist, Unresponsiveness to Lymphoid-Mediated Signals at the Neonatal Follicular Dendritic Cell Precursor Level Contributes to Delayed Germinal Center Induction and Limitations of Neonatal Antibody Responses to T-Dependent Antigens The Journal of Immunology. ,vol. 170, pp. 2824- 2832 ,(2003) , 10.4049/JIMMUNOL.170.6.2824
Becky Adkins, Rong Qing Du, NEWBORN MICE DEVELOP BALANCED TH1/TH2 PRIMARY EFFECTOR RESPONSES IN VIVO BUT ARE BIASED TO TH2 SECONDARY RESPONSES Journal of Immunology. ,vol. 160, pp. 4217- 4224 ,(1998)
Wim Timens, Sibrand Poppema, T Rozeboomuiterwijk, A Boes, Immaturity of the human splenic marginal zone in infancy. Possible contribution to the deficient infant immune response. Journal of Immunology. ,vol. 143, pp. 3200- 3206 ,(1989)
R K Selander, D A Caugant, H Ochman, J M Musser, M N Gilmour, T S Whittam, Methods of multilocus enzyme electrophoresis for bacterial population genetics and systematics Applied and Environmental Microbiology. ,vol. 51, pp. 873- 884 ,(1986) , 10.1128/AEM.51.5.873-884.1986
B Schwartz, P S Moore, C V Broome, Global epidemiology of meningococcal disease. Clinical Microbiology Reviews. ,vol. 2, pp. S118- S124 ,(1989) , 10.1128/CMR.2.SUPPL.S118