Lipoprotein(a), homocysteine, and remnantlike particles: emerging risk factors.

摘要: Although lipoprotein(a) [Lp(a)] was first described more than 35 years ago, adequate prospective data have only recently supported Lp(a) as an independent risk factor for coronary heart disease (CHD). In vitro studies suggest that contributes to atherogenesis directly by cholesterol uptake and indirectly the inhibition of fibrinolysis. patients with CHD or a significant CHD, should be measured treated either niacin estrogen if patient has levels 10 mg/dL mass 30 mg/dL. addition, homocysteine remnantlike lipoprotein are strongly population-based prevalence factors CHD. Homocysteine 14 mumol/L vitamin supplements folate, B6, B12. Remnantlike is product novel immunoassay separates partially hydrolyzed triglyceride-rich remnant particles. The association these particles in women may explain small triglycerides Framingham Heart Study. A clear therapeutic intervention not been documented but include diet, fibric acid derivatives, hydroxymethylglutamyl coenzyme reductase inhibitors.