Structural patterns and histological behaviour of experimental sarcomas

摘要: Summary Methylcholanthrene-induced rat sarcomas were used as a model for the examination of morphological and cytological differentiations in tumours connective tissue. Particular attention was paid to question how far these are comparable human tissue tumours. The histological yields broad spectrum mesenchymal ranging from undifferentiated anaplastic over less differentiated fibrosarcomas malignant fibrous histocytomas well-differentiated fibrosarcomas, myosarcomas haemangiopericytomas. It is worth mentioning that different structures can be encountered within one same tumour. Experimentally induced favoured studying problems histogenesis biological behaviour proliferations soft Already about 40 years ago (Bonser Orr 1939) fact known single carcinogenic hydrocarbon capable induce lesions (cp. Fischer Kuhl 1958). At light microscopic level classified leiomyosarcomas, rhabdomyosarcomas, hemangioendotheliomas, haemangiopericytomas sarcomas. Hence arises whether have developed neoplastic transformation specific histologically defined cell lines fibroblasts, leiomyoblasts etc., or they products cancerization pluripotent progenitor cell. latter idea seems possible because carcinogen responsible formation various tumour (Kazantis Hanbury 1966, Clarke 1969, Roe Carter Paulini et al. 1975). Therefore term “fibrosarcoma” on large scale past (Nettleship Smith 1950) should with caution tumours, especially if other elements For induction such methylcholanthrene has proved very suitable substance. This high percentage after subcutaneous injection rats Bogden 1967). aforementioned variegation view their cytogenesis we rats. In this paper describe general aspects appearances