Periostin and bone marrow fibrosis

摘要: Periostin is a secreted protein that shares structural homology with the insect axon guidance fasciclin 1. expressed predominantly in collagen-rich fibrous connective tissues are subjected to constant mechanical stresses. We have shown previously periostin novel component of subepithelial fibrosis bronchial asthma. Here, we investigated relationship between and bone marrow (BM) fibrosis. was stroma stromal cells BM specimens great extent its expression levels correlated closely grade fibrosis, as estimated by silver staining. However, present study, found no plasma also demonstrated human hTERT secretion enhanced TGF-β, cytokine produced clonal proliferation megakaryocytes and/or monocytes. These results indicate it may play role disease progression.