Neutrophil elastase as a predicting factor for development of acute lung injury.

摘要: Objective To determine whether the development of acute lung injury (ALI) and respiratory distress syndrome (ARDS) associated with systemic inflammatory response (SIRS) can be predicted by plasma neutrophil elastase level. Patients Methods were sequentially enrolled after obtaining informed consent. Twenty-three adult patients SIRS classified into following groups; alone (5 patients), Group A ALI/ARDS (9 patients) that did not require mechanical ventilation, B required ventilation. Blood samples obtained diagnosis SIRS, sequential sampling was performed. Results The level significantly elevated in all patient groups as compared healthy controls (43.7±5.4 ng/ml). levels alone, ALI/ARDS, 126.9±11.0 ng/ml, 316.2±68.9 458.4±132.8 respectively. greater than alone. maximal 13 18 more 220 ng/ml. consistently less ng/ml over study period. serum cytokines these patients, but no statistical significance detected among groups. Conclusion critical is are highly likely to develop ALI/ARDS.