Development and characterisation of a self-microemulsifying drug delivery systems (SMEDDSs) for the vaginal administration of the antiretroviral UC-781
作者： Christopher McConville , David Friend
DOI: 10.1016/J.EJPB.2012.10.007
关键词:
摘要: Abstract UC-781 is highly selective and potent against HIV-1. However, its hydrophobic nature (log P 5.1) lack of aqueous solubility have limited development as a HIV microbicide. Self-microemulsifying drug delivery systems (SMEDDSs) been developed to enhance the water bioavailability drugs, such UC781. In this study, we show UC781-loaded SMEDDS their enhanced release UC781 from hard gelatine capsules, when compared powder only. The majority antiretrovirals being evaluated potential microbicides are hydrophobic. Therefore, formulation offers an alternative approach enhancing vaginal absorption these microbicidal candidates.
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