Morphology of the Lung in Late Septic Shock

摘要: The adult respiratory distress syndrome (ARDS) is sometimes associated with the onset of sustained pulmonary hypertension (Zapol and Snider 1977) accompanying structural remodelling arterial circulation — increased medial thickness preacinar arteries, reduction in peripheral bed appearance muscle walls normally nonmuscular intraacinar arteries (Snow et al. 1982; Meyrick 1986). Animal models acute lung injury, e.g., repeated endotoxemia thoracic irradiation (Meyrick Brigham 1986; Perkett 1986), confirm an association between injury chronic vascular disease but trigger to its development not known. Hypoxia mural pressure have been suggested contribute pathogenesis this Reid 1978; Poiani 1990) our recent data sheep also suggests that or inflammation may play a role 1985, 1987; 1986, 1988). Inflammation occurs rat monocrotaline hyperoxia (Stenmark 1985; Jones 1984). Several clinical conditions support idea be involved occur bronchitis emphysema (Semmens 1974; Magee 1988), cystic fibrosis (Ryland 1975), collagen diseases, AIDS (Mette 1991) ARDS 1977; Snow 1982). Currently, there no effective treatment for patients hypertension.