Synthesis of new allyl palladium complexes bearing purine-based NHC ligands with antiproliferative and proapoptotic activities on human ovarian cancer cell lines.

摘要: A series of new palladium allyl complexes bearing purine-based carbenes derived from caffeine, theophylline and theobromine have been prepared characterized by NMR spectroscopy, elemental analysis in two cases single crystal X-ray diffraction. The cytotoxic proapoptotic activities compounds determined vitro on human ovarian cancer A2780 SKOV-3 cell lines. These experiments shown that the palladium-allyl fragment induces a general cytotoxicity, but choice supporting ligands is paramount importance for achieving best results. In particular 4c, 4d 5d exhibit higher antiproliferative effect (IC50: 0.09, 0.81 0.85 μM respectively) than cisplatin 1.5 μM) cells, 1.7 vs. 5.94 line. Moreover many it has proved cytotoxicity our associated with induction apoptosis.