The Structure of Apolipoprotein A-I in High Density Lipoproteins

摘要: Not long ago, high density lipoproteins (HDL)2 were second class citizens with regard to therapeutic strategies for lowering the risk of atherosclerosis and coronary artery disease (CAD). To date, most successful approaches have focused on better understood pathways cholesterol synthesis low lipoprotein (LDL) production, “forward” transport pathway. For example, statin inhibitors significantly reduces LDL levels resulting in a less atherogenic plasma profile. However, relatively modest improvements mortality conferred by these drugs suggest that other factors also play significant roles defining CAD risk. The recent discoveries HDL-interacting cell surface proteins such as scavenger receptor BI (SR-BI) ATP-binding cassette transporters A1 (ABCA1) G1 (for reviews see Refs. 1 2) helped define steps reverse (RCT), i.e. movement from periphery liver catabolism (3, 4). Additionally, there is growing evidence HDL anti-inflammatory properties may contribute protective effects (5), apparently via specific signaling (6). These fueled new interest target treatment (7). Unfortunately, complete understanding ofHDL function has been hampered lack information its structure molecular basis interactions proteins. This review summarizes latest efforts protein component HDL, apoA-I, various stages RCT