Cutting edge: IL-4-induced protection of CD4+CD25- Th cells from CD4+CD25+ regulatory T cell-mediated suppression.
作者： Luigia Pace , Stefania Rizzo , Cecilia Palombi , Frank Brombacher , Gino Doria
DOI: 10.4049/JIMMUNOL.176.7.3900
关键词:
摘要: CD4(+)CD25(+) T regulatory (Treg) cells are a CD4(+) cell subset involved in the control of immune response. In vitro, murine Treg inhibit CD4(+)CD25(-) Th proliferation induced by anti-CD3 mAb presence APCs. The addition IL-4 to cocultured inhibits cell-mediated suppression. Since all types used coculture express IL-4Ralpha chain, we different combinations cells, and APCs from wild-type IL-4Ralpha(+/+) or knockout IL-4Ralpha(-/-) mice. Results show that engagement chain on renders these resistant Moreover, promotes IL-4Ralpha(+/+)CD4(+)CD25(+) which preserve full suppressive competence. These findings support an essential role signaling for activation indicate IL-4-induced is compatible with their activity.
jimmunol.org参考文章(18)
Afonso R. M. Almeida, Nicolas Legrand, Martine Papiernik, António A. Freitas, Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. Journal of Immunology. ,vol. 169, pp. 4850- 4860 ,(2002) , 10.4049/JIMMUNOL.169.9.4850
David C. Gondek, Li-Fan Lu, Sergio A. Quezada, Shimon Sakaguchi, Randolph J. Noelle, Cutting Edge: Contact-Mediated Suppression by CD4+CD25+ Regulatory Cells Involves a Granzyme B-Dependent, Perforin-Independent Mechanism Journal of Immunology. ,vol. 174, pp. 1783- 1786 ,(2005) , 10.4049/JIMMUNOL.174.4.1783
Luigia Pace, Claudio Pioli, Gino Doria, IL-4 Modulation of CD4+CD25+ T Regulatory Cell-Mediated Suppression Journal of Immunology. ,vol. 174, pp. 7645- 7653 ,(2005) , 10.4049/JIMMUNOL.174.12.7645
Angela M. Thornton, Ciriaco A. Piccirillo, Ethan M. Shevach, Activation requirements for the induction of CD4+CD25+ T cell suppressor function. European Journal of Immunology. ,vol. 34, pp. 366- 376 ,(2004) , 10.1002/EJI.200324455
D. L. Radu, N. Noben-Trauth, J. Hu-Li, W. E. Paul, C. A. Bona, A targeted mutation in the IL-4Rα gene protects mice against autoimmune diabetes Proceedings of the National Academy of Sciences of the United States of America. ,vol. 97, pp. 12700- 12704 ,(2000) , 10.1073/PNAS.230431397
John J. O'Shea, Averil Ma, Peter Lipsky, Cytokines and autoimmunity Nature Reviews Immunology. ,vol. 2, pp. 37- 45 ,(2002) , 10.1038/NRI702
Thomas R. Malek, Allison L. Bayer, Tolerance, not immunity, crucially depends on IL-2 Nature Reviews Immunology. ,vol. 4, pp. 665- 674 ,(2004) , 10.1038/NRI1435
Regula Mueller, Linda M Bradley, Troy Krahl, Nora Sarvetnick, Mechanism Underlying Counterregulation of Autoimmune Diabetes by IL-4 Immunity. ,vol. 7, pp. 411- 418 ,(1997) , 10.1016/S1074-7613(00)80362-3
Jason D Fontenot, Jeffrey P Rasmussen, Marc A Gavin, Alexander Y Rudensky, A function for interleukin 2 in Foxp3-expressing regulatory T cells Nature Immunology. ,vol. 6, pp. 1142- 1151 ,(2005) , 10.1038/NI1263
Thomas R Malek, Aixin Yu, Vladimir Vincek, Paul Scibelli, Lin Kong, CD4 Regulatory T Cells Prevent Lethal Autoimmunity in IL-2Rβ-Deficient Mice: Implications for the Nonredundant Function of IL-2 Immunity. ,vol. 17, pp. 167- 178 ,(2002) , 10.1016/S1074-7613(02)00367-9