Frailty phenotype and frailty index are associated with distinct neuromuscular electrophysiological characteristics in men

摘要: NEW FINDINGS What is the central question of this study? Human frailty characterized by accumulated health complaints, including medical conditions, low physical and psychological function social components. It currently unknown whether condition associated with neuromuscular changes detectable electrophysiology obtained from voluntary involuntary muscle contractions. main finding its importance? A higher likelihood was significantly a smaller size vastus lateralis motor unit potentials during contractions compound action generated electrical stimulation. Importantly, these associations were independent age body mass index. ABSTRACT The purpose study to determine electrophysiological characteristics that are known underlie sarcopenia also more complex syndrome. Eighty-six men [mean (SD) age, 74 (8) years] classed as non-frail (robust), prefrail or frail using criteria phenotype (FP) index (FI). femoral nerve stimulated maximally resulting potential amplitude (CMAP) measured over lateralis. Motor (MUP) assessed intramuscular electromyography (iEMG). Logistic negative binomial regression models determined relationships between FP FI CMAP MUP sizes before after adjustments for Larger lower in fully adjusted models: 1SD level 0.4 (95% confidence interval: 0.2, 0.6; P < 0.01) (40% range) than halving odds [odds ratio: 0.43 0.21, 0.90)] having frail/prefrail phenotype. Greater related values unadjusted models. However, not any model. Smaller MUPs frailty, These results relate syndrome identify remodelling possible contributing factor.