The Tyrosine-Containing Cytoplasmic Tail of CD1b Is Essential for Its Efficient Presentation of Bacterial Lipid Antigens
作者： Robin M Jackman , Steffen Stenger , Agnes Lee , D.Branch Moody , Rick A Rogers
DOI: 10.1016/S1074-7613(00)80539-7
关键词:
摘要: Abstract CD1b is an antigen-presenting molecule that mediates recognition of bacterial lipid and glycolipid antigens by specific T cells. We demonstrate the nine–amino acid cytoplasmic tail contains all signals required for its normal endosomal targeting, single tyrosine a critical component targeting motif. Mutant forms lacking motif are expressed at high levels on cell surface but unable to efficiently present acquired either exogenously or from live intracellular organisms. These results define functional role in physiologic setting importance delivery this appropriate compartments.
elsevier.com
sci-hub.se 参考文章(45)
P A Sieling, S M Behar, E M Beckman, S T Furlong, J P Rosat, D Chatterjee, R Matsumoto, A Melián, S A Porcelli, R L Modlin, CD1c restricts responses of mycobacteria-specific T cells. Evidence for antigen presentation by a second member of the human CD1 family. Journal of Immunology. ,vol. 157, pp. 2795- 2803 ,(1996)
Evan M. Beckman, Steven A. Porcelli, Craig T. Morita, Samuel M. Behar, Stephen T. Furlong, Michael B. Brenner, Recognition of a lipid antigen by CD1-restricted αβ+ T cells Nature. ,vol. 372, pp. 691- 694 ,(1994) , 10.1038/372691A0
M Fukuda, J Viitala, J Matteson, S R Carlsson, Cloning of cDNAs encoding human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. Comparison of their deduced amino acid sequences. Journal of Biological Chemistry. ,vol. 263, pp. 18920- 18928 ,(1988) , 10.1016/S0021-9258(18)37370-8
I. Orme, S. Sturgill-Koszycki, D. G. Russell, Delphi Chatterjee, A. Cooper, T. Van Heyningen, P. Allen, Songmei Xu, Intracellular trafficking in Mycobacterium tuberculosis and Mycobacterium avium-infected macrophages. Journal of Immunology. ,vol. 153, pp. 2568- 2578 ,(1994)
Steven A. Porcelli, The CD1 family: a third lineage of antigen-presenting molecules. Advances in Immunology. ,vol. 59, pp. 1- 98 ,(1995) , 10.1016/S0065-2776(08)60629-X
Steven A. Porcelli, Michael B. Brenner, Masahiko Sugita, Assembly and retention of CD1b heavy chains in the endoplasmic reticulum. Journal of Immunology. ,vol. 159, pp. 2358- 2365 ,(1997)
Michael S. Marks, Hiroshi Ohno, Tomas Kirchnausen, Juan S. Bonracino, Protein sorting by tyrosine-based signals: adapting to the Ys and wherefores. Trends in Cell Biology. ,vol. 7, pp. 124- 128 ,(1997) , 10.1016/S0962-8924(96)10057-X
H Ohno, J Stewart, M. Fournier, H Bosshart, I Rhee, S Miyatake, T Saito, A Gallusser, T Kirchhausen, J. Bonifacino, Interaction of tyrosine-based sorting signals with clathrin-associated proteins Science. ,vol. 269, pp. 1872- 1875 ,(1995) , 10.1126/SCIENCE.7569928
Masahiko Sugita, Michael B. Brenner, Association of the Invariant Chain with Major Histocompatibility Complex Class I Molecules Directs Trafficking to Endocytic Compartments Journal of Biological Chemistry. ,vol. 270, pp. 1443- 1448 ,(1995) , 10.1074/JBC.270.3.1443
Valérie Pinet, Marco Vergelli, Roland Martini, Oddmund Bakke, Eric O. Long, Antigen presentation mediated by recycling of surface HLA-DR molecules Nature. ,vol. 375, pp. 603- 606 ,(1995) , 10.1038/375603A0