Functional Expression of CXCR4 in S. cerevisiae: Development of Tools for Mechanistic and Pharmacologic Studies
作者： W.-B. Zhang , Z.-X. Wang , J. L. Murray , N. Fujii , J. Broach
DOI: 10.1007/978-3-662-05403-1_9
关键词:
摘要: Chemokines are cytokines that program directed migration of leukocyte subsets (Loetscher et al. 2000). These small proteins (~8–14 kDa) form the largest family secreted intercellular messengers, having over 43 members recognized at this time. The is characterized by presence four positionally conserved cysteine residues and subdivided into branches based on relationship two amino-proximal cysteines: C-C, C-X-C, C-X3-C, C. Cellular signals for chemokines transduced G-protein coupled receptor (GPCR) also cosegregate along these subdivisions (Murphy It now in addition to promoting inflammation through recruitment subsets, play a central role directing development tissues outside hemato-lymphoid system.
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Hao Xu, Evamaria I. Petersen, Steffen B. Petersen, M. Raafat El-Gewely, Random Mutagenesis Libraries: Optimization and Simplification by PCR BioTechniques. ,vol. 27, pp. 1102- 1108 ,(1999) , 10.2144/99276BM02
P. Samama, S. Cotecchia, T. Costa, R.J. Lefkowitz, A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model. Journal of Biological Chemistry. ,vol. 268, pp. 4625- 4636 ,(1993) , 10.1016/S0021-9258(18)53442-6
Christine Klein, Jeremy I. Paul, Karen Sauvé, Mary M. Schmidt, Loretta Arcangeli, John Ransom, Joshua Trueheart, John P. Manfredi, James R. Broach, Andrew J. Murphy, Identification of surrogate agonists for the human FPRL-1 receptor by autocrine selection in yeast Nature Biotechnology. ,vol. 16, pp. 1334- 1337 ,(1998) , 10.1038/4310
C Niehrs, W B Huttner, D Carvallo, E Degryse, Conversion of recombinant hirudin to the natural form by in vitro tyrosine sulfation. Differential substrate specificities of leech and bovine tyrosylprotein sulfotransferases. Journal of Biological Chemistry. ,vol. 265, pp. 9314- 9318 ,(1990) , 10.1016/S0021-9258(19)38850-7
Pius Loetscher, Bernhard Moser, Marco Baggiolini, Chemokines and their receptors in lymphocyte traffic and HIV infection. Advances in Immunology. ,vol. 74, pp. 127- 180 ,(1999) , 10.1016/S0065-2776(08)60910-4
Conrad C. Bleul, Michael Farzan, Hyeryun Choe, Cristina Parolin, Ian Clark-Lewis, Joseph Sodroski, Timothy A. Springer, The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature. ,vol. 382, pp. 829- 833 ,(1996) , 10.1038/382829A0
Hirokazu Tamamura, Akane Omagari, Shinya Oishi, Taisei Kanamoto, Naoki Yamamoto, Stephen C Peiper, Hideki Nakashima, Akira Otaka, Nobutaka Fujii, Pharmacophore identification of a specific CXCR4 inhibitor, T140, leads to development of effective anti-HIV agents with very high selectivity indexes. Bioorganic & Medicinal Chemistry Letters. ,vol. 10, pp. 2633- 2637 ,(2000) , 10.1016/S0960-894X(00)00535-7
K King, H. Dohlman, J Thorner, M. Caron, R. Lefkowitz, Control of yeast mating signal transduction by a mammalian beta 2-adrenergic receptor and Gs alpha subunit Science. ,vol. 250, pp. 121- 123 ,(1990) , 10.1126/SCIENCE.2171146
Jean-Marc Navenot, Zi-xuan Wang, John O Trent, James L Murray, Qin-xue Hu, Lynn DeLeeuw, Patrick S Moore, Yuan Chang, Stephen C Peiper, Molecular anatomy of CCR5 engagement by physiologic and viral chemokines and HIV-1 envelope glycoproteins: differences in primary structural requirements for RANTES, MIP-1α, and vMIP-II binding Journal of Molecular Biology. ,vol. 313, pp. 1181- 1193 ,(2001) , 10.1006/JMBI.2001.5086
Y. Feng, C. C. Broder, P. E. Kennedy, E. A. Berger, HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor Science. ,vol. 272, pp. 872- 877 ,(1996) , 10.1126/SCIENCE.272.5263.872