Motor control and cognition deficits associated with protein carbamoylation in food (cassava) cyanogenic poisoning: Neurodegeneration and genomic perspectives.
作者： F.A. Rwatambuga , E.R. Ali , M.S. Bramble , J.E. Gosschalk , Morris Kim
DOI: 10.1016/J.FCT.2020.111917
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摘要: Abstract A case-control design determined whether konzo, an upper motoneuron disease linked to food (cassava) toxicity was associated with protein carbamoylation and genetic variations. Exon sequences of thiosulfate sulfurtransferase (TST) or mercaptopyruvate (MPST), plasma cyanide detoxification rates, 2D-LC-MS/MS albumin were assessed in 40 children [21 konzo-affected 19 putatively healthy controls, mean (SD) age: 9.2 (3.0) years] subjected cognition motor testing using the Kaufman Assessment Battery Bruininks/Oseretsky Test, respectively. Konzo significantly higher levels carbamoylated peptides 206–219 (LDELRDEGKASSAK, pep1) after adjusting for age, gender, concentrations BUN [regression coefficient: 0.03 (95%CI:0.02–0.05), p = 0.01]. Levels pep1 negatively correlated performance scores at all modalities proficiency (r = 0.38 0.61; p
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