Metastasis: Circulating Tumor Cells in Small Cell Lung Cancer
作者： Gerhard Hamilton , Doris Moser , Maximilian Hochmair
DOI: 10.1016/J.TRECAN.2016.02.006
关键词:
摘要: Small cell lung cancer (SCLC) is distinguished by excessive numbers of circulating tumor cells (CTCs) in extended and recurring disease. This malignancy has a poor prognosis due to rapid emergence chemoradioresistant relapses after first-line chemotherapy. In vitro expansion several CTC lines allowed for detailed study the contribution these metastasis. Generation CTCs involves establishment co-cultures recruitment macrophages specific cytokines. All show E-cadherin-positive epithelial-like spontaneous assembling into very large tumorospheres. Such multicellular aggregates seem be responsible observed broad resistance limited access drugs, quiescent layers, hypoxic cores.
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